目的 探讨肿瘤医院重症监护室内获得性粘质沙雷菌感染的分布以及耐药性特征,为临床预防和控制粘质沙雷萄感染提供依据.方法 对我院重症监护室分离的36株粘质沙雷菌的资料进行细菌分布以及耐药性分析.结果 分离的36株粘质沙雷菌,其中痰标本19株(52.8％)；粘质沙雷菌对头孢呋肟、头孢噻吩和头孢唑啉等一代和二代头孢菌素耐药率较高;对四代头孢菌素以及亚胺培南、阿米卡星、复方新诺明和环丙沙星的敏感性较好.结论 粘质沙雷菌耐药机制复杂,而且对抗生素具有多重耐药性,根据药敏试验合理应用抗菌素十分重要.%Objective To investigate distribution and resistance for acquired infection of Serratia marcescens in a intensive care unit of cancer hospital, and provide reliable evidence for preventing and monitoring nosocomial Serratia marcescens infection. Methods 36 strains of Serratia marcescens were separated during January 2006 to October 2009. Distribution and resistant analysis were performed. Results Serratia marcescens had much higher antimicrobial resistance to the 1st and 2nd generation cephalosporin. They were all susceptible to imipenem, 4th generation cephalosporin, amikacin, trimethoprim-sulfamethoxazole and ciprofloxacin. Conclusion Ser show multi-drug resistance. It is very important to rationally use antibiotics according to susceptibility testing results.
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