支气管哮喘急性发作患者死亡相关因素分析

摘要

Objective To explore the risk factors associated with the mortality in hospitalized patients with asthma exacerbations. Methods A total of 30 patients died of asthma exacerbations and 35 discharged patients recoverd from asthma exacerbations were retrospectively analyzed. The relevant factors influencing prognosis were compared. Results There were significant differences in the prevalences of respiratory failure type Ⅱ, pneumonia, Cor Pulmonale, renal failure, digestive tract hemorrhage, hypertension and mechanical ventilation. By the multiple Logistic regression analysis,the Cor Pulmonale(the OR value 8.528,95 ％ CI 1. 574 ～46.200 ) and invasive ventilation(the OR value 55.031,95 ％ CI 9.459～320. 148 ) were the independence risk factors for mortality of asthma exacerbations. Conclusion The Cor Pulmonale and invasive ventilation are the important associated risk factors for mortality of asthma exacerbations.%目的 探讨影响支气管哮喘急性发作住院患者死亡率的危险因素.方法 收集1999年3月～2010年9月在华西医院呼吸内科住院的因支气管哮喘急性发作死亡病例30例作死亡组,与同期缓解出院的35例病人作为对照组,比较两组间可能影响预后的因素,对差异有统计学意义的因素行Logistic回归分析.结果 两组一般情况大致相似.Ⅱ型呼吸衰竭、肺炎、肺心病、肾功能衰竭、消化道出血、高血压病、机械通气等方面的病例数及百分比与对照组比较有显著性的差异,多重Logistic回归分析提示肺心痛(OR 8.528,95%CI 1.574～46.200)、有创通气(OR55.031,95%CI9.459～320.148)为死亡的独立危险因素.结论 支气管哮喘急性发作住院患者合并肺心痛、需要有创通气死亡风险显著增高.