Objective To observe the callus-I intragastric administration security and provide the basis for clinical medication safety. Methods Mice were treated with callus-I intragastric or water with the largest tolerant volumn by intragastric administration. The survival rate was observed 3 days after treatment. The body weight, appetite, behavior, activity, appetite and stools were observed 7 days after treatment. Results The mice with gavage of Callus- I ultrasonic atomizing agent had survived. The indexes of the two group were not significantly different (P>0. 05). Conclusion Callus- I ultrasonic atomizing agent is relatively safe and can be used for clinical research and treatment.%目的 观察愈伤Ⅰ号小鼠灌胃的安全性,为临床安全用药提供依据.方法 用愈伤Ⅰ号或饮用水,以最大给药浓度及可承受的最大体积对小鼠一次性灌胃,3天后对比存活情况；并采用一日最大给药量灌胃,7天后对比愈伤Ⅰ号与饮用水灌胃后,小鼠体重和食量、外表行动、反应活动、饮水量及大小便情况.将小鼠最大灌胃量通过公式转换为成人每日用量.结果 愈伤Ⅰ号超声雾化剂灌胃的小鼠全部存活,具有安全性；上述观察指标两组对比,差异不明显(P＞0.05)；小鼠一日最大给药量为3.36g,经换算相当于成人临床日用量的133倍.结论 愈伤Ⅰ号超声雾化剂使用比较安全,可用于临床研究及治疗.
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