危重症患者并发抗生素相关性肠炎51例临床分析

摘要

Objective To summarize clinical features and treatment of antibiotic-associated colitis (AAC) experience of the surgical ICU critically patients. Methods Clinical data of 51 patients were treated in hospital surgical ICU 2007 to 2012 was analyzed retrospectively. Results 51 cases of patients had antibiotic-associated colitis during the treatment with antibiotics during or after antibiotics treatment. With treatment of vancomycin, 46 patients were cured, 5 cases died due to the primary disease. Conclusion Critically patients with low immunity, long-term broad-spectrum antibiotic used in combination lead to the high incidence of antibiotic-associated colitis. Once the diagnosis of critically patients should be rational use of antibiotics to reduce the occurrence of AAC and treated with the norvancomycin.%目的 总结外科ICU危重症患者并发抗生素相关性肠炎(AAC)的临床特点及治疗经验.方法 对医院外科ICU2007～2012年收治的51例患者的临床资料进行回顾性分析.结果 51例患者均在抗生素治疗期间或停用抗生素后发生抗生素相关性肠炎,及时停用相关抗生素和使用去甲万古霉素后,46例治愈,5例因原发病死亡.结论 危重症患者免疫力低下,长期广谱抗生素联合使用导致抗生素相关性肠炎的发病率极高.对危重症患者应合理使用抗生素以减少AAC的发生,一旦确诊,可使用去甲万古霉素进行治疗.