Objective To research the therapeutic effect of the medication in treatment of peptic ulcer in aged patient. Methods 48 cases of Hp infection in aged patients with peptic ulcer were randomly divided into omeprazole + amoxicillin. combined with urazolidone treatment (control group, 24 cases) and esomeprazole + amoxicillin, combined with furazolidone treatment group (experimental group, 24 cases). The medication changes in symptoms and side effects were observed. Results The ulcer healing rate in the experimental group was significantly higher than that in the control group. The Hp eradication rate of experimental group was 95. 83%. while the control group was 66. 67%. There was significantly statistical difference. Hp eradication rate of experimental group was significantly higher than that of the control group. The control group had nausea, headache, loss of appetite and other side effects and adverse reactions, while the experiment group was not found. Conclusion The effect of esomeprazole in inhibiting gastric acid secretion and promoting ulcer healing is very powerful. and has fewer side effects.%目的 比较两种用药方法对老年人消化性溃疡病变的治疗效果.方法 把48例幽门螺杆菌(Hp)阳性老年消化性溃疡患者随机分为奥美拉唑+阿莫西林联合呋喃唑酮治疗组24例(对照组)和埃索美拉唑+阿莫西林联合呋喃唑酮治疗组24例(实验组).观察记录服药后症状变化及副反应,并随访一年.结果 实验组溃疡愈合率明显高于对照组(P＜0.05).实验组Hp的根除率为95.83％;对照组为66.67％,实验组Hp的根除率明显高于对照组(P＜0.05).对照组出现恶心、头痛、食欲不振等副作用及不良反应.实验则未发现.结论 埃索美拉唑抑制胃酸分泌和促进溃疡愈合的疗效较好,副作用小.
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