目的 探讨新疆维族与汉族前列腺疾病患者PSA系列水平的差异性.方法 采用微粒子免疫荧光捕获法检测维族与汉族前列腺疾病患者血清fPSA和tPSA水平及其比值.结果 分析显示维族与汉族患者fPSA和tPSA水平均呈现前列腺癌组＞前列腺增生组＞慢性前列腺炎组和对照组(FfPSA=92.94,FtPSA=1642,P＜0.01；FfPSA=63.67,FtPSA=2074,P＜0.01),F/T比值亦均表现为前列腺癌组分别明显低于前列腺增生组、慢性前列腺炎组和对照组(F=8.17,P＜0.01；F=12.77,P＜0.01).族别分析显示在前列腺癌组维族与汉族患者tPSA水平呈现统计学显著性差异,汉族患者略高于维族(t=2.16,P＜0.05)；在前列腺增生组两民族fPSA和tPSA水平间分别存在统计学显著性差异,均表现为汉族患者高于维族(t=7.31,t=20.86,P＜0.01).结论 民族间血清PSA系列水平测定无明显的差异性,尤其tPSA与F/T联合监测更有助于维族与汉族患者前列腺疾病的鉴别诊断.%Objective To explore differences of PSA series in patients with Prostatic disease between Uygur and Han nationality of Xinjiang. Methods Microparticle enzyme immunoassay (MEIA) was used to detect serum tPSA and fPSA level and its F/T ratio in Uygur and Han patients with prostatic disease. Results Analysis showed prostate cancer >benign prostate hyperplasia>chronic prostatitis and control groups (F,psa = 92. 94, F(psa == 1642, P<0. 01; Fipsa = 63. 67,Fn.sA = 2074,P<0. 01) on tPSA and fPSA level in Uygur and Han patients, and the F/T ratio of prostate cancer group was obviously lower than that of benign prostate hyperplasia-, chronic prostatitis and control groups respectively (F = 8. 17,P<0. 01; F=12. 77, P<0. 01) in Uygur and Han patients. The difference was found that tPSA level of Han nationality was higher than that of Uygur 0=2. 16,P<0. 05) in prostate cancer groups and tPSA or fPSA of Han was separately higher of Uygur ((=7. 31, t = 20. 86, P<0. 01). Conclusion The level of serum PSA series demonstrate no obvious differences and especially tPSA and F/T co-detection is helpful to differential diagnosis of Prostatic disease between Uygur and Han patients.
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