Objective To investigate the effect of combination of clopidogrel and aspirin in acute coronary syndrome patients. Methods 89 patients with acute coronary syndrome were enrolled in our hospital from April 2008 to September 2010,they were divided into observation group (clopidogrel + aspirin, n = 46) and control group(aspirin,n = 43). the clinical effect, the level of troponin and complication were compared in two groups. Results Clinical curative effect comparison, the excellent rate and total efficacy rate were 72. 4% ,95. 2%,significantly higher than 62. 8% ,91. 5% in control group (P＜0. 05). The level of troponin comparison, the excellent rate and total efficacy rate were 77. 2% ＞ 96. 1% significantly higher than 67. 4% ,89. 9% (P＜0. 05). The major complication was subcutaneous hemorrh- αge in both group,3 patients in observation group (6. 5%) and 2 patients in control group(4. 7%)(P＞0. 05). Conclusion Combination of clopidogrel and aspirin in treating acute coronary syndrome patients has significant clinical efficacy.%目的 探讨氯吡格雷联合阿司匹林治疗急性冠脉综合征(ACS)患者的临床疗效和安全性.方法 选择2008年4月～2010年9月住院治疗的89例ACS患者,根据抗血小板药物的差异,将患者分为观察组(氯吡格雷+阿司匹林,n=46)和对照组(阿司匹林组,n=43),比较两组患者临床疗效、肌钙蛋白变化和并发症.结果 两组患者临床疗效比较,观察组显效率和总有效率(72.4％、95.2％)高于对照组(62.8％、91.5％),差异有统计学意义(P＜0.05)；观察组肌钙蛋白变化显效率和总有效率(分别为77.2％、96.1％)高于对照组(67.4％、89.9％),差异有统计学意义(P＜0.05).两组患者发生出血情况主要表现为皮下出血点,经减量或停药后自行好转,均未做特殊处理.其中观察组发生3例(6.5％),对照组2例(4.7％),二者相比,差异无统计学意义(P＞0.05).结论 氯吡格雷联合阿司匹林治疗急性冠脉综合征疗效显著,安全性好,可在临床推广应用.
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