经皮冠状动脉介入治疗术后标准双抗血小板治疗和长期双抗血小板治疗的预后对比

摘要

Objective:To discuss the effect of standard double antiplatelet and long term dual antiplatelet therapy on prognosis of patients with coronary heart disease after percutaneous coronary intervention(PCI). Method:The clinical data of 200 patients with coronary artery disease who returned to our hospital after PCI from January 2015 to December 2017 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,100 cases in each group.The observation group received long term dual antiplatelet therapy,while control group received standard double antiplatelet therapy.The platelet aggregation rate,erythrocyte count and platelet count before and after treatment,effective endpoint events and safety endpoint events between two groups were compared.Result:Before treatment and 3,6 and 12 months after treatment, the platelet aggregation rate,erythrocyte count and platelet count in two groups were compared,the differences were not statistically significant(P>0.05).18 and 24 months after treatment,the erythrocyte count in two groups were compared,the differences were not statistically significant(P>0.05),but the platelet aggregation rate and platelet count in observation group were lower than those of control group,the differences were statistically significant(P0.05).Conclusion:Long term dual antiplatelet therapy after PCI can safely and effectively inhibit platelet aggregation,reduce the incidence of postoperative cardiovascular adverse events in patients with coronary heart disease.%目的:探讨经皮冠状动脉介入治疗(PCI)术后标准双抗血小板和长期双抗血小板对冠心病患者预后的影响.方法:回顾性分析2015年1月-2017年12月在上级医院行PCI术后回本院复诊的冠心病患者200例的临床资料,按治疗方法不同将其分为观察组和对照组,各100例.观察组给予长期双抗血小板治疗,对照组给予标准双抗血小板治疗.比较两组治疗前后的血小板聚集率、红细胞计数、血小板计数以及有效性终点事件和安全性终点事件发生率.结果:治疗前及治疗3、6、12个月,两组血小板聚集率、红细胞计数、血小板计数比较,差异均无统计学意义(P>0.05);治疗18、24个月,两组红细胞计数比较差异均无统计学意义(P>0.05),但观察组血小板聚集率、血小板计数均低于对照组,比较差异均有统计学意义(P0.05).结论:PCI术后使用长期双抗血小板治疗可安全有效地抑制血小板聚集,减少冠心病患者术后心血管不良事件的发生率.