血小板参数、凝血功能指标与妊娠晚期子痫前期的相关性分析

摘要

目的:探究血小板参数、凝血功能指标与妊娠晚期子痫前期的相关性.方法:选取2015年6月-2017年1月于本院收治的妊娠晚期子痫前期患者130例, 按照子痫前期病情严重程度将其分为轻度组59例和重度组71例, 另选取同期就诊无合并症的妊娠晚期孕妇60例为对照组.检测并观察三组孕妇D-二聚体 (D-D) 、纤维蛋白原 (FIB) 、凝血酶原时间 (PT) 、活化部分凝血酶时间 (APTT) 等凝血指标, 以及血小板分布宽度 (PDW) 、血小板平均体积 (MPV) 、血小板计数 (PLT) 、血小板压积 (PCT) 等血小板参数.结果:对照组、轻度组PDW、MPV、PLT、PCT水平与重度组比较, 组间差异均有统计学意义 (P<0.05) ;对照组PDW、MPV、PLT水平与轻度组比较, 组间差异均有统计学意义 (P<0.05) .轻度组、重度组D-D、FIB、PT、APTT水平与对照组比较, 组间差异均有统计学意义 (P<0.05) ;轻度组的D-D、FIB、APTT水平与重度组比较, 组间差异均有统计学意义 (P<0.05) .结论:与正常晚期妊娠相比, 妊娠晚期重度子痫前期患者存在明显的高凝状态及血小板活化现象, 故妊娠期检测凝血功能及血小板功能对预防子痫及血栓形成具有一定的诊断价值.%Objective:To explore the correlation of platelet parameters, coagulation function indicators and preeclampsia in late pregnancy.Method:A total of 130 patients with preeclampsia treated in our hospital from June 2015 to January 2017 were selected and divided into mild group of 59 cases and severe group of 71 cases according to the severity of preeclampsia.In addition, 60 women with late pregnancy who had not comorbidities during the same period were selected as the control group.The coagulation parameters such as D-dimer (DD), fibrinogen (FIB), prothrombin time (PT), activated partial thrombin time (APTT), and platelet distribution width (PDW) were measured and observed in the three groups.Platelet parameters such as mean platelet volume (MPV), platelet count (PLT), platelet pressure (PCT) of three groups were observed.Result:The difference of PDW, MPV, PLT, PCT levels between the control group and the mild group compared with the severe group was statistically significant (P<0.05).The differences of PDW, MPV and PLT levels between the control group and the mild group were statistically significant (P<0.05).The levels of D-D, FIB, PT and APTT in the mild group and the severe group were significantly higher than those in the control group (P<0.05).The D-D, FIB and APTT levels in the degree group compared with the severe group, the differences between the groups were statistically significant (P<0.05).Conclusion:Compared with normal late pregnancy, patients with severe preeclampsia in late pregnancy have significant hypercoagulability and platelet activation.Therefore, detection of coagulation and platelet function during pregnancy may have certain diagnostic value for the prevention of eclampsia and thrombosis.