胸腺五肽联合地氯雷他定治疗慢性特发性荨麻疹的临床观察

摘要

目的：探讨胸腺五肽联合地氯雷他定治疗慢性特发性荨麻疹的临床疗效。方法：治疗慢性特发性荨麻疹患者180例，按照随机数字表法将其分为治疗组和对照组各90例。治疗组：口服地氯雷他定分散片5 mg，1次/d，同时胸腺五肽针1 mg加入0.9%氯化钠注射液250 mL，静脉滴注，1次/d；对照组：口服地氯雷他定片5 mg，1次/d。两组均连续用药4周后，随访观察12周，评定疗效并记录皮损变化和不良反应。结果：治疗组痊愈率为95.6%，总有效率为97.8%，对照组痊愈率为90%，总有效率为95.6%。两组短期症状控制效果都非常有效，差异无统计学意义（P>0.05）。两组痊愈患者复发情况观察结果显示，治疗组停药超过12周未复发（优等）病例52例（60.5%），对照组11例（13.6%）；治疗组停药后4周以内复发（差等）病例9例（10.4%），对照组38例（46.9%），两组比较差异均有统计学意义（P<0.01）。研究结果显示远期疗效治疗组明显优于对照组，治疗组能有效减少治疗后复发率。结论：胸腺五肽联合地氯雷他定治疗慢性特发性荨麻疹疗效明显，能有效控制风团和瘙痒，副作用小，复发率低，远期疗效明显高于单用地氯雷他定治疗。%Objective:To investigate the clinical efficacy of Thymopentin-5 combined with desloratadine in treatment of chronic idiopathic urticaria.Method:The treatment of chronic idiopathic urticaria patients 180 cases,randomly divided into the treatment group and the control group,90 cases in each group.Treatment group:Oral desloratadine dispersible tablets 5 mg,qd,at the same time the Thymopentin-5 1 mg added 0.9%sodium chloride injection 250 mL,intravenous drip,qd;Control group:Oral desloratadine tablets 5 mg,qd. The two groups were treated for 4 weeks,followed up for 12 weeks,evaluated and recorded the efficacy and adverse reaction in skin lesions.Result:The cure rate of the treatment group was 95.6%,the total effective rate was 97.8%,the cure rate of the control group was 90.0%,the total effective rate was 95.6%,and the difference of two indicates above between the two groups were no statistically significant(P>0.05). The two group of patients relapse were observed. The results showed,the treatment group was more than 12 weeks in withdrawal recurrence(top)of 52 cases(60.5%),11 cases in the control group(13.6%),the treatment group 4 weeks after withdrawal recurrence within 9(low)cases(10.4%),38 cases in the control group(46.9%),and the difference of two indicates above between the two groups were no statistically significant(P<0.01).Conclusion:Thymopentin-5 combined with desloratadine in treatment of chronic idiopathic urticaria obvious curative effect,can effectively control the nettle rash and itching,little side effect,low recurrence rate,long-term effect is obviously higher than that of single desloratadine therapy.