布林佐胺治疗青光眼的临床疗效和安全性

摘要

Objective:To evaluate the clinical efficacy and safety of Brinzolamide in treatment of glaucoma.Method:Glaucoma in 32 patients were treated from February 2011 to April 2012 in our hospital for the study,patients with a total of 56 OHT and postoperative residual glaucoma,primary open-angle glaucoma,were randomly dividedbrinzolamide(1%)treatment for the two groups that the treatment group and the control group,16 cases in each group of 28 eyes,the treatment group and the control group,treatment with timolol maleate(0.5%),comparing the two drugshypotensive effect as well as the course of treatment,or after treatment of adverse symptoms.Result:After the two groups of patients using the drug,the intraocular pressure have decreased significantly(P<0.05),the difference was statistically significant;average IOP decreased after the treatment of the two groups of patients showed no significant difference(P>0.05)does not havestatistically significant;two groups of patients after treatment before the changes in blood pressure and medication was no significant difference(P>0.05)was not statistically significant;no significant changes in heart rate in patients of the treatment group,the control group in patients with heart rate suppression,the difference being statisticallysignificance(P<0.05),the two groups of patients did not occur during treatment of serious clinical adverse reactions,patients significant systemic side effects.Conclusion:Brinzolamide treatment of glaucoma patients clinically significant ocular hypotensive action,heart rate inhibition,is a safe and effective clinical ideal drug for the treatment of glaucoma, worthy of promotion and application of a wide range of clinical.%　　目的：观察布林佐胺治疗青光眼患者的临床疗效以及安全性。方法：选取本院2011年2月-2012年4月期间收治的青光眼患者32例为研究对象，患者共计56只高眼压症以及术后残余青光眼、原发性的开角型青光眼，将其随机分为两组即治疗组和对照组，每组16例28只眼，治疗组采用布林佐胺（1%）治疗，对照组采用马来酸噻吗洛尔（0.5%）治疗，比较两药物降眼压的作用以及治疗过程中或者治疗后的不良反应。结果：两组患者在使用药物之后，眼压都有明显的下降，治疗前后比较差异均具有统计学意义（P<0.05）；两组患者治疗后眼压下降的平均值比较差异无统计学意义（P>0.05）；两组患者在治疗后血压变化和用药前比较差异无统计学意义（P>0.05）；治疗组患者心率无明显变化，对照组患者出现了心率抑制，比较差异具有统计学意义（P<0.05），两组患者在治疗过程中均未发生严重的临床不良反应，无一例患者出现明显的全身性副作用。结论：布林佐胺治疗青光眼患者具有十分显著的降眼压作用，无心率抑制作用，是一种安全有效的治疗青光眼的理想药物，值得在临床上推广和应用。