慢性阻塞性肺疾病伴哮喘患者血清白介素-6及转化生长因子β1水平的临床研究

摘要

Objective:To explore the effect and correlation of IL-6 and TGF-β1 in chronic obstructive pulmonary disease with asthma patients. Method:To detect the concentration of IL-6 and TGF-β1 in serum from 48 cases with ELISA,and 36 healthy people were the control group.Result:Compared with the control group,the concentration of serum IL-6 and TGF-β1 was significantly increased in chronic obstructive pulmonary disease with asthma patients,obviously difference(P<0.05).Conclusion:Both IL-6 and TGF-β1 involve in the airwas inflammatory reaction and plays an important role in the development and progression of COPD with asthma.%　　目的：探讨白介素-6(IL-6)及转化生长因子β1(TGF-β1)在慢性阻塞性肺疾病(COPD)伴哮喘患者的作用及相关性.方法：采用酶联免疫法( ELISA)检测48例慢性阻塞性肺疾病伴哮喘患者血清中IL-6和TGF-β1的浓度，并设36例健康者作为对照组.结果：慢性阻塞性肺疾病伴哮喘患者的血清中IL-6与TGF-β1的水平均显著高于对照组，比较差异具有统计学意义(P<0.05).结论：IL-6与TGF-β1共同参与了COPD伴哮喘的气道炎性反应，在慢性阻塞性肺疾病伴哮喘的发生发展过程中起着重要作用.