浆细胞病骨髓细胞形态学特征及其临床意义

摘要

Objective:To explore the plasma cell morphologic characteristics of bone marrow cell in their different disease. Method:To analyze the plasma cell morphologic characteristics of 61 cases diagnosed with plasma cell disease in Wright’s staining method. Result:57.4%cases showed a higher proportion of blasts,macytes myeloma cell;16.4%cases showed the plasma cells increased more than 10%,with grain,erythroid proportional reduction and grain mature obstacles;8.2%cases with higher mature plasma cells;6.6%cases with only hyperplasia anemia,infection,grain,erythroid proportion reduction;and lymphoid plasma cells type displayed in 4.9%patients in bone marrow cells;3.3%patients showed a reticular cells type;3.3%patients behaved flaming plasma cell type. Conclusion:The morphology of plasma cell is an important basis for diagnosis of plasma cell disease;the correct type,classification is significance to estimating prognosis and forecasting monoclonal immunoglobulin disease as well.%　　目的：探讨不同浆细胞病各自的骨髓细胞形态学特征.方法：采用瑞氏染色法对61例已确诊为浆细胞病的患者进行骨髓细胞形态学分析.结果：57.4%的患者骨髓细胞形态学显示原始、幼稚骨髓瘤细胞比例增高；16.4%的患者表现为浆细胞比例增高>10%，伴粒、红比例减低且粒系成熟障碍；8.2%的患者显示成熟型浆细胞比例增高；6.6%的患者仅表现为增生性贫血、感染、粒、红比例减低；4.9%的患者显示淋巴样浆细胞；3.3%的患者显示网状细胞型；3.3%的患者显示火焰状浆细胞型.结论：骨髓浆细胞形态学是浆细胞病诊断的重要依据，正确的分型、分类对估计预后和预测某种单克隆免疫球蛋白病有积极意义.