慢性肾炎患者血清IL-2、IL-6、TNF-α水平变化及意义分析

摘要

Objective:To study the variation and clinical significance of serum IL-2,IL-6 and TNF-α of patients with chronic nephritis. Method:56 patients with chronic nephritis in our hospital from July 2010 to June 2012 were selected as observation group,and 42 personnel with health examination at the same time were selected as control group,then the serum IL-2,IL-6 and TNF-αof observation group with different severity and types and control group were detected and compared.Result:The serum IL-2 of observation group was lower than that of control group,serum IL-6 and TNF-αwere higher than those of control group,IL-2 of patients with severe and hypertensive type chronic nephritis were lower than those of other patients,serum IL-6 and TNF-αwere higher than those of other patients,all P<0.05,there were all significant differences.Conclusion:The detection of serum IL-2,IL-6 and TNF-αof patients with chronic nephritis is helpful to understand the severity and types of disease.%　　目的：探讨慢性肾炎患者血清IL-2、IL-6、TNF-α水平的变化规律及其临床意义.方法：选取2010年7月-2012年6月于本院进行治疗的56例慢性肾炎患者为观察组，同期的42名于本院进行健康体检的人员为对照组，将观察组中不同严重程度、分型和对照组患者的血清IL-2、IL-6、TNF-α水平进行检测及比较.结果：观察组的血清IL-2低于对照组，血清IL-6及TNF-α水平则高于对照组，同时重度患者和高血压型患者的血清IL-2低于其他患者，血清IL-6及TNF-α水平则高于其他患者，比较差异有统计学意义(P<0.05).结论：慢性肾炎患者血清IL-2、IL-6、TNF-α水平的检测有利于了解患者的疾病严重程度和分型.