目的：研究颅脑损伤患者血清C-反应蛋白（CRP）、血糖（Glu）的动态变化及临床意义。方法：85例颅脑外伤患者按照病情计分法分为重型组21例、中型组29例、轻型35例共三组，采用生化分析仪测定颅脑外伤患者外伤入院后6 h、1、3、7、14、28 d血清中CRP、Glu水平。结果：所有颅脑外伤患者均出现血清CRP上升，但重型组血清CRP含量在外伤入院后6 h内明显升高，之后持续上升，7 d达到高峰，且持续时间长，28 d仍较高；而轻中型患者上升幅度较重型组小，轻中型组均为第3天达到高峰，之后逐渐下降。Glu水平在颅脑损伤患者中与CRP的变化一样有随时间逐渐下降的趋势。三组各时间点除Glu-6 h轻型与中型组、Glu-14 d轻型与中、重型组、Glu-28 d各组间，CRP-6 h轻型与重型、中型与重型组比较差异无统计学意义（P>0.05）；其余相同时间点组间比较差异均有统计学意义（P<0.05）。结论：CRP、Glu联检可作为监测颅脑外伤敏感指标，对于预示病情的发生、发展和转归具有较好的临床意义。%Objective:To explore the clinical values of the dynamic changes of C-reaction protein(CRP)and glucose(Glu)in patients with traumatic brain injury. Method:85 cases of traumatic brain injury were divided into three groups(the severe group for 21 cases,the medium group for 29 cases,the light group for 35 cases)based on the GCS scores,the concentrations of CRP and Glu in serum were determined by biochemical analyzer at 6 h,on 1,3,7,14, 28 d after injury.Result:All patients with traumatic brain injury were serum CRP increased,but significantly increased the content of serum CRP in the severe group 6 hours after injury,then continued to rise,reaching a peak at 7 days,and lasted for a long time,28 days is still high;while the light and medium groups were higher than the severe group,the light and medium groups for third days to reach the peak,then gradually declined. Glu levels had gradually decreased over time trends in the changes in CRP patients with traumatic brain injury. The three groups at the time in addition to Glu-6 h of the light and medium group,Glu-14 d in the light group and the medium,severe group,Glu-28 d of each group,CRP-6 h in the light and medium,severe group comparison had no statistically significant differences(P>0.05);the same time point comparisons had statistically significant differences between groups(P<0.05).Conclusion:CRP,Glu as monitoring brain trauma sensitive indicator for indicating the occurrence of the disease,development and clinical significance have better outcomes.
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