血浆脑钠肽的检测对急性心肌梗死患者的早期诊断价值

摘要

目的：探讨血浆BNP在急性心肌梗死患者发病后的动态变化及其对AMI的早期诊断价值。方法：选择稳定型心绞痛（SA）患者22例、不稳定型心绞痛（UA）患者24例及健康对照组20例测定血浆BNP浓度，急性心肌梗死（AMI）患者41例于症状发作后2、4、6、24 h测定血浆BNP浓度。结果：UA组及AMI各时间点BNP水平均明显高于SA组（P<0.01）；且随着症状发作时间的延长而明显增高（P<0.01）。AMI患者症状发作4、6 h ROC曲线下面积分别为0.819和0.898。结论：AMI患者发病2 h血浆BNP就开始增高，且增高的水平与发病时间长短明显相关；血浆BNP用于早期诊断急性心肌梗死有非常好的诊断功能。%Objective:To discuss the dynamic changes of BNP in the patients of AMI and the clinical significance of the early diagnosis of AMI. Method:Plasma BNP in 22 SA cases,24 UA cases,20 healthy cases were tested and the plasma BNP of 41 AMI cases also were tested in 2,4,6 and 24 h after the onset of AMI.Result:BNP level of AMI group and UA group were obviously higher than that of SA group(P<0.01).Plasma BNP level in 4,6,24 h after onset of AMI were obviously higher than that of UA group(P<0.01).4 h and 6 h after AMI onset the surface area under ROC curve were 0.819 and 0.898. Conclusion:AMI patients have an increased plasma BNP level obviously 2 hours after the onset of AMI,and the BNP level increases significantly with the extension of tine. 4 h and 6 h after the onset of AMI the plasma BNP level have good diagnostic value for AMI.