维生素B12联合多西环素治疗神经型布氏杆菌病的疗效观察

摘要

Objective:To observe the clinical efficacy of vitamin B12 combined with doxycycline in treatment of neurological brucellosis.Method:65 outpatients and hospitalized patients in our hospital were selected,they were randomly divided into the treatment group for 35 cases and the control group for 30 cases,the treatment group was given vitamin B12 combined with doxycycline,the control group was only given doxycycline treatment,six weeks as a course of treatment.The clinical symptoms,physical signs of improvement,clinical effect and adverse reaction after treatment between the two groups were observed and compared.Result:After six weeks of treatment,the two groups after treatment were improved,the fever and headache treatment showed no significant differences(P>0.05),there were statistically significant differences in the aspect of fatigue,bone and joint pain,meningeal irritation sign,numbness,paralysis between the two groups(P<0.05).The total efficiency of treatment group was 94.3%,it was significantly higher than 66.7%of control group,the difference was statistically significant(P<0.05).There was no significant difference between the two groups in adverse circumstances(P>0.05).Conclusion:Vitamin B12 combined with doxycycline in the treatment of neurobrucellosis is an effective method of treatment,is worthy of clinical promotion.%目的：观察维生素B12联合多西环素治疗神经型布氏杆菌病的临床疗效。方法：选取本院门诊及住院患者65例，将其随机分为治疗组35例和对照组30例。治疗组采用维生素B12联合多西环素治疗，对照组单用多西环素治疗，疗程为6周。观察比较两组患者治疗后临床症状、体征好转情况、临床疗效及不良反应发生情况。结果：经过6周的治疗，两组治疗后均好转，在发热和头痛的治疗上差异均无统计学意义（P>0.05），而治疗组在乏力、骨关节痛、脑膜刺激征、手足麻木、面瘫等方面与对照组比较差异均有统计学意义（P<0.05）。治疗组的总有效率94.3%明显高于对照组的66.7%，差异有统计学意义（P<0.05）。两组不良反应情况无明显差异（P>0.05）。结论：维生素B12联合多西环素治疗神经型布氏杆菌病是一种有效的治疗方法，值得在临床上推广。