氯吡格雷联合阿司匹林和低分子肝素治疗不稳定型心绞痛疗效和安全性观察

摘要

目的：探究氯吡格雷联合阿司匹林和低分子肝素治疗不稳定型心绞痛的临床效果以及安全性。方法：选择在本院接受医治的不稳定型心绞痛患者120例，平均分为两组，每组60例。试验组使用氯吡格雷、阿司匹林、低分子肝素治疗；对照组则使用阿司匹林、低分子肝素治疗。密切观察两组患者经药物治疗后的临床效果、监测指标、体内凝血标志等情况。结果：对照组不稳定型心绞痛发作次数、硝酸酯类抗心绞痛药物使用剂量明显高于试验组；对照组总有效率为60.00%，明显低于试验组的91.67%，差异具有统计学意义（P<0.05）。结论：使用氯吡格雷同时联合应用阿司匹林以及低分子肝素治疗不稳定型心绞痛具有很好的临床效果，较为安全有效，可以在临床实践中广泛使用。%Objective:To explore the clinical efficacy and safety of clopidogrel combined with aspirin and low molecular heparin in the treatment of unstable angina pectoris(UAP).Method:120 UAP patients of our hospital were selected as the study objects,and divided into two groups,60 cases in each group .The experimental group was treated by clopidogrel,aspirin and low molecular heparin,control group was treated by aspirin and low molecular heparin.Clinical efficacy,monitoring index,coagulation sign inside the body of two groups were closely observed.Result:The UAP attack times,dosage of nitrates antianginal drugs of control group were significantly higher than those of experimental group;and the total effective rate of control group(60.00%)was significantly lower than that of experimental group(91.67%),with significant differences in clinic(P<0.05).Conclusion:Efficacy and safety of clopidogrel combined with aspirin and low molecular heparin in the treatment of UAP are good,it could be widely applied in clinic.