探讨反复呼吸道感染患儿T细胞免疫功能与血清皮质醇关系

摘要

Objective:To study the relationship of immune T cell function and serum cortisol in children with recurrent respiratory tract infection.Method:20 children with recurrent respiratory tract infections in our hospital from June 2013 to November 2014 were selected as the treatment group,20 cases of healthy children were selected as a control group.Used flow cytometry,ECL method in the treatment group,children with the disease progression,disease stabilization period (four weeks after respiratory symptoms disappear),healthy children,T cells were detected in the serum levels of serum cortisol (COR) of content changes,T cell immune function and serum cortisol relationship were compared and analyzed.Result:RRTI children with recurrent respiratory tract infection,stable disease due to T cell CD3+,CD4+ secretion of a large number of children with accessibility in vivo serum COR indicators of normal children,but when the disease progresses,the body as a result of children with T cells secrete CD3+,CD4+ reduced,resulted in lower levels in vivo serum COR.Conclusion:Children with recurrent respiratory tract infection of T cells in vivo serum levels of serum cortisol (COR) to monitor changes in content,RRTI understand the etiology and pathogenesis,a key factor in reducing the incidence and reduce the number of children with recurrent respiratory tract infections,and help clinical treatment,prognosis and reduce disease progression,reduce the heavy economic burden on patients and government high medical costs.%目的：研究反复呼吸道感染（RRTI）患儿T细胞免疫功能与血清皮质醇关系。方法：选取2013年6月-2014年11月本院收治的20例反复呼吸道感染患儿为治疗组，选取健康儿童20例为对照组。使用流式细胞术、电化学发光法，在治疗组患儿病情进展期、病情稳定期（呼吸道症状消失后4周）、健康儿童，分别检测血清中T细胞水平、血清皮质醇（COR）的含量变化，对比分析T细胞免疫功能与血清皮质醇关系。结果：RRTI患儿出现反复呼吸道感染后，病情稳定时由于T细胞CD3+、CD4+大量分泌的影响，患儿体内血清COR指标可接近正常儿童；而病情进展时，由于患儿体内T细胞分泌CD3+、CD4+减少，导致体内血清COR水平降低。结论：通过对RRTI患儿体内血清T细胞水平、血清皮质醇（COR）的含量变化的监测，了解RRTI的病因病机，减少发病的关键因素，减少RRTI患儿的数量，帮助指导临床治疗、预后判断，减少疾病恶化，减轻患者及政府高额医疗费用的沉重经济负担。