NF-κB与早发型及晚发型子痫前期的相关性研究

摘要

目的：研究早发型（孕周<32周）及晚发型（孕周≥32周）子痫前期患者胎盘中NF-κB的活性强度。方法：选择子痫前期患者40例，其中早发型患者20例为早发型子痫前期组，晚发型患者20例为晚发型子痫前期组；正常足月妊娠孕妇30例为对照组。用免疫组化法观察各组胎盘NF-κBp65的分布和活性强度的差异。结果：子痫前期组胎盘NF-κBp65染色均较正常组明显增强，且早发型组较晚发型组染色明显增强，两组比较差异有统计学意义（P<0.05）。结论：早发型和晚发型子痫前期患者胎盘NF-κB活化增多，活性增强，及其所参与的免疫炎症反应，可能与其发病机制相关。%Objective: To explore the relationship of NF-κB in placenta with early-onset (gestational age <32 weeks)and late-onset(gestational age ≥32 weeks)preeclampsia.Method:40 PE women were selected and divided into early-onset PE group of 20 cases and late-onset PE group of 20 cases.The normal control group were 30 healthy normotensive pregnancy.Immunohistochemistry was employed to show the location distribution and quantity of NF-κBp65 in placenta of preeclampsia.Result:NF–κBp65 in placenta of preeclampsia was stronger expression than that of control group,and was stronger expression in early-onset preeclampsia than that in late-onset preeclampsia,the differences were statistically significant(P<0.05).Conclusion: It suggests that NF–κB participate in the pathogenesis of preeclampsia.Increasing NF–κB activity in placenta induces the immune inflammatory reaction,which may be related to the etiology of early-onset and late-onset preeclampsia.