氯氮平对男性精神分裂症患者骨密度的影响

摘要

Objective: To investigate the effect of non-classical antipsychotic drugs on bone mineral density in male patients with schizophrenia.Method: The bone mineral density between the two groups were determinated with absorptiometry to learn bone mineral density. General situation was surveyed, combined with the general situation to analyze the related factors associated with bone density.Result: The normal BMD values in the case group and the control group was 30.00%, 81.25%, respectively, the osteoporosis in the case group and the control group was 52.50%, 6.25%, respectively. There were significant differences on BMD values between the two groups (P<0.05). There was no difference on age, body mass index between the two groups, there were differences in smoking, milk factors (P<0.05). Conclusion: Compared with the healthy population, the BMD on patients with the long-term use of antipsychotic drug significantly.%目的：探讨非经典抗精神病药物对男性精神分裂症患者骨密度的影响。方法：应用骨密度仪对病例组及对照组进行骨密度测定，了解两组人群的骨密度状况。对两组人群的一般情况进行调查，结合一般情况的相关因素进行骨密度与相关性分析。结果：病例组和对照组骨密度值正常者分别为30.00%、81.25%，病例组和对照组骨质疏松症者分别为52.50%、6.25%。两组骨密度值比较差异有统计学意义（P<0.05）。两组年龄、体重指数比较差异无统计学意义，但吸烟、牛奶因素比较差异有统计学意义（P<0.05）。结论：长期服用抗精神病药物的患者骨密度值与健康人群相比明显降低。