中西医结合治疗方案对肺结核肺阴虚证患者生活质量的影响

摘要

Objective:To observe the effect of integrated traditional Chinese and Western medicine treatment program on the quality of life of newly diagnosed pulmonary tuberculosis patients with pulmonary yin deficiency,and to provide scientific basis for improving the quality of life of tuberculosis patients and the prevention and cure of tuberculosis.Method:A randomized parallel clinical trial was conducted in which 693 newly diagnosed pulmonary tuberculosis patients with pulmonary yin deficiency syndrome were divided into experimental group (338 cases)and control group(355 cases).The patients in both groups were treated with the same chemotherapy regimen.The experimental group was served Ziyin Runfei Particles,2 times a day,a course of 6 months.The change of total score of quality of life of SF-36 was observed and compared.Result:The results of FAS showed that there was no significant difference in the total score of life quality between the two groups(P>0.05).After two months and six months of treatment,the total scores of the two groups were statistically significant(P<0.05), and the experimental group than those in control group(P=0.005,P<0.001).The results of PPS analysis showed that there was no significant difference in the total score of life quality between the two groups before and after treatment(P>0.05).After two months and six months of treatment,the total scores of the two groups were statistically significant(P<0.05),and the experimental group than those in control group(P=0.007,P<0.001). Conclusion:Integrative traditional Chinese and Western medicine treatment program can significantly improve the quality of life of pulmonary tuberculosis patients with pulmonary yin deficiency syndrome.%目的：观察中西医结合治疗方案对初治继发性肺结核肺阴虚证患者生活质量的影响，为提高肺结核病患者的生存质量和结核病防治工作提供科学依据。方法：采用随机平行对照临床研究，将符合标准的693例初治继发性肺结核肺阴虚证患者分为试验组338例和对照组355例，两组均采用统一化疗方案治疗，试验组加服滋阴润肺免煎颗粒，2次/d，疗程为6个月，观察比较两组SF-36量表总分变化。结果：FAS分析结果表明，治疗前，两组的生活质量量表总分比较，差异无统计学意义（P>0.05）；治疗2、6个月后，两组的总分均高于治疗前（P<0.05），且试验组均高于对照组，差异均有统计学意义（P=0.005，P<0.001）。PPS分析结果表明，治疗前两组的生活质量量表总分比较，差异无统计学意义（P>0.05）；治疗2、6个月后均高于治疗前（P<0.05），且试验组的生活质量量表总分均优于对照组，差异均有统计学意义（P=0.007，P<0.001）。结论：中西医结合治疗方案可明显提高肺结核肺阴虚证患者的生活质量。