目的：观察丁氏溃结灌肠液气药灌肠法治疗不同部位的溃疡性结肠炎（ulcerative colitis， UC）的临床疗效。方法：采用病例系列研究方法，纳入2012年4月-2013年9月在南京中医药大学第三附属医院肛肠科炎症性肠病专病门诊就诊的患者48例，内镜下评分为轻、中度病变，并同意接受气药灌肠治疗。根据发病部位分为E2组（病变累及脾曲以远）和E3组（广泛病变累及脾曲以近乃至全结肠）两个亚组，以丁氏溃结灌肠液通过气药灌肠仪进行气药灌肠治疗，观察两组患者治疗前后改良Mayo评分及临床症状积分变化、血白细胞、C反应蛋白、血红蛋白、血白蛋白等指标的变化。结果：E2组和E3组患者治疗前后改良Mayo评分、临床症状积分比较，差异均有统计学意义（P<0.05），两组治疗前后血沉（ESR）变化比较，差异有统计学意义（P<0.05）。E2组总有效率为95.0%，E3组为85.7%，两组患者治疗前后各指标组间比较差异均无统计学意义（P>0.05），未见明显并发症。结论：丁氏溃结灌肠液对于轻中度UC疗效确切，气药灌肠法用于控制近端病变是安全有效的。%Objective:To evaluate the clinical effect of Dingshikuijieguanchangye with Gas Enema in patients with ulcerative colitis(UC).Method:Forty-eight outpatient clinic or hospital UC patients(patients information were from the inflammatory bowel disease clinic,department of colorectal diseases,the 3rd Affiliated hospital of Nanjing University of Chinese Medicine from April 2012 to September 2013) were enrolled in the case series study.All subjects were received endoscopy,whose lesions were mild and moderate degree,and accepted the gas enema with Dingshikuijieguanchangye.All patients were classified into two groups according to their location of lesions,E2 group(including patients whose lesions were at the distal of splenic flexure) and E3 group (including patients whose lesions were involved in the proximal part of or the whole intestine).Patients were treated with Gas Enema with Dingshikuijieguanchangye.Clinical indicators included modified Mayo score,clinical symptom scores, blood leukocytes,C-reactive protein,hemoglobin,serum albumin,etc.Result:The modified Mayo score,the clinical symptom scores and ESR of two groups were changed statistically significant(P<0.05).The effective rate of the treatment group and the control group were 95.0% and 85.7%, there was no statistical significance(P<0.05) and no obviously adverse events were observed in both groups.Conclusion:Dingshikuijieguanchangye is effective in mild to moderate UC,and Gas Enema can be used for UC with lesions in the proximal intestine.
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