比较盐敏感性与非盐敏感性高血压的联合药物治疗

摘要

Objective To explore the value of transabdominal and transvaginal ultrasonography in diagnosis of pregnancy. Methods 120 cases in hospitalized patients with mild to moderate hypertension, after the salt load test tests to determine the 60 cases of salt-sensitive hypertension group (SS), another 60 patients as a non-salt-sensitive hypertension group (NSS) , and then the two groups were in groups of 30 cases were randomly divided into two groups, each with felodipine tablets combined perindopril and indapamide sustained release tablets tablets combined perindopril tablets for 12 weeks, measuring treatment change after 24 h of each index. Results SS group compared with the NSS group, dif erent levels of FPG and Cr were statistical y significant ( <0.01), the difference FINS, LVMI, MAU, BMI, HOMA-IR are also statistically significant ( <0.05 ); SS group of patients is the use of joint training indapamide perindopril treatment, and the detection of indicators are within the normal range, the difference was statistical y significant ( <0.05); NSS group of patients is the use of felodipine combined perindopril treatment, and its detection indicators are located within the normal range, the dif erence was statistical y significant ( <0.05).Conclusion Salt-sensitive hypertension obvious target organ damage, for indapamide and perindopril combination therapy, rather than salt-sensitive patients for felodipine combination therapy with perindopril.%目的探讨盐敏感性与非盐敏感性高血压对靶器官的损害和联合药物治疗的差异。方法在住院的轻中度高血压患者中选取120例,经过盐负荷试验测试,确定60例为盐敏感性高血压组(SS),另选择60例作为非盐敏感性高血压组(NSS),再将这两组分别以每组30例随机分为两小组,分别用非洛地平片联合培哚普利片和吲达帕胺缓释片联合培哚普利片治疗12w,测量治疗前后24 h各指标的变化。结果 SS组与NSS组相比,FPG和Cr水平的不同有统计学意义(<0.01),FINS、LVMI、MAU、BMI、HOMA-IR的差异亦有统计学意义(<0.05)；SS组中的患者是使用培吲达帕胺联合哚普利进行治疗的,各项检测指标均位于正常范围内,差异有统计学意义(<0.05)；NSS组中的患者是使用非洛地平联合培哚普利进行治疗的,其各项检测指标都位于正常范围之内,差异有统计学意义(<0.05)。结论盐敏感性高血压患者的靶器官有明显损害,适于吲达帕胺与培哚普利联合药物治疗,而非盐敏感性患者适于非洛地平与培哚普利联合治疗。