Experimental Study of a New Operative Procedure for Non -Ischemic Dilated Cardiomyopathy - Overlapping Cardiac Volume Reduction Operation

摘要

Objectives To assess a newly devised procedure of cardiac volume reduction without resection of cardiac muscle and evaluated in experimental settings. Methods Ten beagle dogs underwent a rapid pacing leading to heart failure for 3 weeks and received the left ventricular reduction termed overlapping cardiac volume reduction operation (OLCVR) ,which consisted of a longitudinal incision in left ventricular (LV) free wall, sutures of the left marginal to the septal wall, and the right marginal to LV free wall.A slope of the linear preload recruitable stroke work relationship (Mw) , with a X - intercept (Vo) were calculated as the precise indicators of left ventricular systolic function. The constant of isovolumic pressure decay (Tau) and a peak filling rate (PFR) were also calculated as the indicators of LV diastolic function.Results LV end -diastolic dimensions was significantly reduced by OLCVR (43±2 to 25±1;mm).Fractional shortening was significantly improved by OLCVR (11±2 to 30±4;%). Mw (erg cm^-3*10^3)was also significantly improved (21±2 to 33±3 (p <0. 001 ) ) , whereas Vo, Tau and PFR did not show significant changes. Conclusions The OLCVR significantly increased in the early LV systolic function without detrimental effects on diastolic function. This procedure may become a therapeutic option for end - stage cardiomyopathy.