The Contrast Study on Serum Collagen Metabolism between Essential Hypertension and Normal Control

摘要

Objectives To investigate serum concentration of procollagen type Icarboxyterminal peptide (PIP), type Ⅲ aminopeptide (PⅢP) and type Icollagen telopeptide (ICTP) in essential hypertension (EH). Methods Serum levels of PIP, PⅢP and ICTP in 42 EH patients and 30 healthy control were measured by radioimmunoassays. Results In EH patients,serum concentration of PIP, PⅢP was significantly higher than that in 30 healthy control. Although EH patients did tend to exhibit a higher serum ICTP concentration than normal control subjects, the difference was not statistically significant. EH patients with left ventricular hypertrophy exhibited higher values of PIP (P 0. 05 ). Conclusions The results suggest that PI P and PⅢP are sensitive serum markers of myocardial collagen synthesis. Myocardial fibrosis may be due to the excessive synthesis and insufficient degradation of collagen. PIP, PⅢP and ICTP may be indirect markers of myocardial fibrosis.