63株嗜麦芽寡养单胞菌的临床分布与耐药性分析

摘要

Objective To investigate the clinical distribution and drug resistance of Stenotrophomonas maltophilia. Methods The clinical distribution and drug resistance analysis for 63 isolates of Stenotrophomonas maltophilia were performed by VITEK-2 COMPACT system and Kirby-Bauer (K-B)method.The results were analyzed statistically. Results The isolation rate was the highest in respiratory specimens .There was a highest isolation rate of 87.3%.The samples were mainly obtained from the wards of Neonatology Department (1 7.4%)and Thoracic Surgery(1 7.4%), followed by Respiratory Department (4.3%) and Intensive Care Unit (ICU ) (1 4.3%).The 63 isolates of Stenotrophomonas maltophilia were highly resistant to imipenem,and the resistance rate was 1 00.0%.The resistance rates to levofloxacin,minocyline and triethoprim-sulfamethoxazole were 1 .6%,3.2% and 3.2%.Conclusions It should enhance drug resistance monitoring of Stenotrophomonas maltophilia.Treatment based on drug susceptibility test should be adapted as soon as possible.%目的：了解嗜麦芽寡养单胞菌的临床分布及对抗菌药物的耐药性。方法采用 VITEK-2 COMPACT全自动微生物鉴定仪及纸片扩散（K-B）法对分离的63株嗜麦芽寡养单胞菌的来源分布、药物敏感性结果进行统计分析。结果63株嗜麦芽寡养单胞菌在临床标本中分布以痰液为主，占87．3％；感染主要发生在新生儿科为17．4％和胸外科17．4％；其次为呼吸科14．3％和重症监护病房（ICU）14．3％；嗜麦芽寡养单胞菌对亚胺培南耐药率为100．0％；而对左氧氟沙星、米诺环素、磺胺甲口恶唑-甲氧苄啶耐药率较低分别为1．6％、3．2％、3．2％。结论应加强对嗜麦芽寡养单胞菌耐药性监测，以指导临床根据药物敏感性试验结果合理选择抗菌药物。