染色体介导 AmpC β-内酰胺酶表达的分子调控机制的研究进展

摘要

细菌产生β-内酰胺酶引起临床抗感染治疗的失败已成为全球性的医疗保健问题，AmpC β-内酰胺酶（简称 AmpC 酶）是其中重要的一种，有关其诱导表达的分子机制的研究日渐更新，现就 AmpC 酶染色体介导的调控机制的研究现状进行综述。%Bacterial resistance to beta-lactamase antibiotics through producing beta-lactamase has become a worldwide healthy care problem.AmpC beta-lactamase (AmpC)is a major one of beta-lactamases.Extensive research has focused on the molecular regulation mechanism pertaining to induction.The recent researches on the regulation mechanism about the expression of chromosomally-mediated AmpC are reviewed.