肿瘤标志物对女性生殖道癌及乳腺癌联合筛查的临床价值

摘要

Objective To investigate the diagnostic role of the combined determination of serum alpha fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 153(CA153)and carbohydrate antigen 125(CA125)in female genital tract cancer and breast cancer.Methods Totally,55 female genital tract cancer and breast cancer patients,55 benign inflammatory patients and 55 healthy subjects were enrolled.Serum levels of AFP,CEA,CA199,CA153 and CA125 were determined,and the results were analyzed statistically.The sensitivities and specificities of the 5 markers for the diagnosis of female genital tract cancer and breast cancer were compared.Results The levels of AFP,CEA,CA199,CA153 and CA125 in cancer group were higher than those in benign inflammatory and healthy control groups(P<0.05).The sensitivity and specificity of the combined determination of the 5 markers were higher than those of the single determinations.Conclusions The combined determination of the 5 markers has a diagnostic value in the screening of female genital tract cancer and breast cancer,and it is helpful for early screening and early diagnosis.%目的 探讨血清甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原153(CA153)、糖类抗原125(CA125)联合检测对女性生殖道癌及乳腺癌的诊断价值.方法 选取女性生殖道癌及乳腺癌患者(癌症组)55例、良性炎症患者55例、健康普查者55名,分别检测其血清AFP、CEA、CA199、CA153、CA125水平,分析各组间结果的差异,并比较5项指标单独或联合检测诊断女性生殖道癌及乳腺癌的敏感性和特异性.结果 癌症组AFP、CEA 、CA199、CA153、CA125水平显著高于良性炎症组和健康普查组(P<0.05).5项指标联合检测诊断女性生殖道癌及乳腺癌的敏感性、特异性均明显高于单项检测.结论 5项肿瘤标志物联合检测对女性生殖道癌及乳腺癌具有较高的诊断价值,有助于疾病的早期筛查和早期诊断.