原发性闭角型青光眼的分子生物学研究进展

摘要

原发性闭角型青光眼(PACG)是由遗传及环境因素相互作用所致的复杂疾病,其房角关闭的机制尚不清楚.对PACG相关基因的研究有助于探明PACG的发病机制,同时对PACG的早期诊断和治疗具有重要意义.全基因组关联研究(GWAS) 及多中心合作的发展使得近年来国内外对PACG的易感基因研究越来越多.文章对PACG相关的研究背景及分子生物学研究进展进行综述,进一步探讨PACG的发病机制.%Primary angle-closure glaucoma(PACG) is a complex disease caused by the interaction of multiple genes and environmental factors,with strong genetic predisposition. The study of PACG-related genes can investigate the pathogenesis of PACG,and it is of significance for the early diagnosis and treatment of PACG. Genome-wide association studies(GWAS) and multicenter cooperation lead to more and more studies on susceptibility genes to PACG at home and abroad in recent years. The research background of PACG and the progress of molecular biology are reviewed,and the pathogenesis of PACG is investigated further.