2项肿瘤标志物检测在氩氦刀冷冻治疗晚期胰腺癌中的作用

摘要

Objective To evaluate the application value of carbohydrate antigen 19-9(CA19-9) and carcinoem-bryonic antigen (CEA ) detection in patients with advanced pancreatic cancer after cryosurgery therapy . Methods Clinical data of 72 patients with advanced pancreatic cancer ,receiving cryosurgery treatment in this hospi-tal from 2008 to 2011 ,were retrospectively analyzed .Results The Ⅳ stage survival time in patients with normal or increased serum level of CA19-9 before operation were(6 .00 ± 1 .67) and(5 .88 ± 4 .81) months ,without statistical difference(P> 0 .05) .Those in patients with normal or increased serum level of CEA before operation were (7 .87 ± 6 .13) and(5 .43 ± 3 .42) months ,with statistical difference(P<0 .01) .Those in patients with decreased or increased serum level of CA19-9 after treatment were (7 .07 ± 4 .86) and(8 .65 ± 5 .71) months ,without statistical difference (P>0 .05) .Those in patients with decreased or increased serum level of CEA after treatment were (7 .00 ± 4 .66) and (9 .67 ± 6 .5) months ,without statistical difference (P>0 .05) .Conclusion CEA might be with higher clinical appli-cation value than CA19-9 ,and preoperative detection could be with more significance than postoperative detection .%目的评价肿瘤标志物血清糖类抗原19-9（CA19-9）、癌胚抗原（CEA）检测在氩氦刀冷冻治疗晚期胰腺癌中的作用。方法回顾性分析本院2008～2011年收入住院晚期胰腺癌病例72例，记录氩氦刀冷冻术前后肿瘤标志物CA19-9、CEA的变化。结果手术前CA19-9值正常的患者Ⅳ期生存期（6．00±1．67）个月，CA19-9值异常的患者Ⅳ期生存期（5．88±4．81）个月，两者差异无统计学意义（P＞0．05）；手术前CEA值正常的患者Ⅳ期生存期（7．87±6．13）个月，CEA值异常的患者Ⅳ期生存期（5．43±3．42）个月，两者差异有统计学意义（P＜0．01）。手术后CA19-9值下降的患者Ⅳ期生存期（7．07±4．86）个月，CA19-9值上升的患者Ⅳ期生存期（8．65±5．71）个月，两者差异无统计学意义（P＞0．05）；手术后CEA值下降的患者Ⅳ期生存期（7．00±4．66）个月，CEA值上升的患者Ⅳ期生存期（9．67±6．50）个月，两者差异无统计学意义（P＞0．05）。结论肿瘤标志物CEA比CA19-9更有意义，且术前检测比术后检测更有意义。