α-硫辛酸对2型糖尿病心脏自主神经病变患者心率变异性的影响

摘要

Objective To evaluate the clinical effects of α-lipoic acid on heart rate variability (HRV) in type 2 diabetes mellitus (T2DM ) patients with cardiac autonomic neuropathy .Methods Eighty-six cases of T2DM patients with cardiac autonomic neuropathy were randomly divided into the treatment group (n=44) and the control group (n=42) .The control group was treated with traditional treatment of anti-diabetics ,anti-hyperlipidemia and anti-hy-pertension ,while the patients in the treatment group were administered with α-lipoic acid 600 mg intravenously guttae qd for 4 weeks .The changes of the HRV parameters in all patients were closely monitored with a 24-hoter .Results With the better altered physiopathologic syndromes ,the HRV parameters in the patients of the treatment group had a significant improvement after 4-week treatment as against before treatment ,and there were significances in compari-son with control group (P<0 .05) .Conclusion α-lipoic acid is effective for cardiac autonomic neuropathy in patient with T2DM and it could improve patients`HRV and clinical symptoms .%目的：观察α-硫酸锌对2型糖尿病（T2DM ）心脏自主神经病变患者心率变异性（HRV）的影响。方法选择2012年6月至2013年12月武汉大学人民医院住院和门诊T2DM合并心脏自主神经病变患者86例为研究对象，随机分为治疗组44例和对照组42例。对照组患者仅给予通常的降糖、降脂和降压等治疗手段，治疗组患者在对照组基础上给予α-硫酸锌600 mg静脉滴注，每天1次，总疗程4周。观察临床症状，并运用24 h动态心电图检测所有患者在治疗前、后HRV指标的变化。结果治疗组HRV较治疗前明显提高，自主神经症状明显好转，与对照组相比，差异有统计学意义（P＜0．05）。结论α-硫酸锌治疗糖尿病心脏自主神经病变的疗效显著，可改善患者H RV。