Objective To observe the treatment effect of captopril combined low molecular heparin in nephrot-ic syndrome .Methods Sixty and eight patients with nephrotic syndrome were collected from Chongqing cancer hos-pital ,which were randomly divided into control group and observation group .Conventional treatment were used in the control group ,captopril combined with low molecular heparin were added in the observation group .cholesterol , triglyceride ,urine protein ,whole blood viscosity ,hematocrit ,fibrinogen ,hematocrit of pigeon before and after treat-ment were compared .Results Total effective rate of observation group was 92 .1% ,which was significantly higher than the control group′s 83 .3% ,the difference was statistically significant (P<0 .05) .The observation group′s cho-lesterol ,triglyceride ,urine protein ,whole blood viscosity ,hematocrit ,fibrinogen ,hematocrit of pigeon were significant lower than those of the control group (P<0 .05) .Conclusion On the basis of conventional treatment ,captopril and low molecular heparin could significantly improve curative effect ,renal function and high coagulation state on pa-tients with nephrotic syndrome .%目的：观察卡托普利联合低分子肝素治疗肾病综合征的临床效果。方法选择本院收治的68例肾病综合征患者为研究对象。对照组30例患者，给予常规治疗28 d；观察组38例患者，在常规治疗的基础上给予卡托普利联合低分子肝素治疗28 d。观察并比较两组患者治疗前后胆固醇、三酰甘油、肌酐、清蛋白、尿蛋白、全血高切黏度、全血低切黏度、血浆黏度、血浆纤维蛋白原、血细胞比容等指标变化情况。结果观察组治疗总有效率达92．1％，明显高于对照组的83．3％，比较差异有统计学意义（ P＜0．05）。治疗28 d后，观察组胆固醇、三酰甘油、尿蛋白、全血黏度、血浆黏度、血浆纤维蛋白原、血细胞比容等指标明显低于对照组，比较差异有统计学意义（P＜0．05）。结论在常规治疗的基础上加用卡托普利联合低分子肝素治疗肾病综合征，可明显提高疗效，改善肾功能及高凝状态，值得临床推广应用。
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