Objective To establish reference interval of thyroid hormones in pregnant women of central and southern district of Hebei Province .Methods A total of 9 721 cases of pregnant women form the Forth Hospital of Shijiazhuang were enrolled ,including 2 309 cases at early phase with average age of (27 .8 ± 3 .7)years old ,4 364 ca-ses at middle phase with average age of (28 .0 ± 3 .6)years old and 3 048 case at late phase with average age of (28 .0 ± 3 .7)years old .Serum levels of thyrotropic-stimulating hormone (TSH) ,free triothyrone (fT3) and free thy-roxine (fT4) were analyzed to establish reference interval .Results Data of TSH was with nonnormal distribution , and should be exchanged for normal distribution by square root .Serum level of TSH was lower in early phase than that in middle and late phases ,but serum levels of and fT 3 and fT4 were higher (P<0 .05) .TSH displayed raising tendency ,while fT3 and fT4 showed downturn in whole pregnancy .Reference intervals ,established according to 95%confidence intervals ,were different with those indicated by reagent kits .Conclusion This study could supply bases for the establishment of reference intervals of thyroid hormones in pregnant women of central and southern district of Hebei Province ,and might be helpful to correctly evaluate thyroid function in pregnant women .%目的：建立冀中南地区不同孕期妇女甲状腺激素参考区间。方法选取2011年1月至2012年8月于本院就诊的9721例妊娠妇女纳入本研究，其中孕早期2309例，平均年龄（27．8±3．7）岁；孕中期4364例，平均年龄（28．0±3．6）岁；孕晚期3048例，平均年龄（28．0±3．7）岁。分析所有入组对象血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（fT3）、游离甲状腺素（fT4）水平，并建立各孕期参考区间。结果TSH数据为非正态分布，需将其进行平方根转换为正态分布。两独立样本均数比较的 t检验结果显示，不同孕期妇女血清TSH、fT3和fT4比较差异均有统计学意义（P＜0．05），TSH水平随孕期增长呈上升趋势，fT3、fT4水平则呈下降趋势。根据95％置信区间所建立的不同孕期各指标的参考区间之间及其与试剂盒标称参考区间之间存在一定的差异。结论本研究结果能够为建立冀中南地区不同孕期妇女甲状腺激素水平参考区间提供依据，有助于正确评价妊娠期妇女的甲状腺功能。
展开▼
