饮食疗法联合优思弗对妊娠期肝内胆汁淤积症患者母婴结局的影响

摘要

目的：探讨饮食疗法联合优思弗对妊娠期肝内胆汁淤积症患者母婴结局的影响。方法选取成都医学院第一附属医院住院治疗患有妊娠期肝内胆汁淤积症具有不良饮食习惯的患者80例作为研究对象，分为对照组和观察组，对照组给予单纯优思弗治疗，观察组给予饮食疗法联合优思弗治疗，1个月后评价两组患者治疗前、后瘙痒评分生化指标及妊娠结局。结果两组患者干预前瘙痒评分差异无统计学意义（P＞0．05），干预后观察组患者瘙痒评分明显低于对照组，对照组患者干预后与干预前相比，血清胆汁酸（TBA）、天门冬氨酸氨基转移酶（AST）水平有显著下降；观察组患者干预后与干预前相比，TBA、AST、碱性磷酸酶（ALP）水平相比均有显著下降；干预后观察组患者TBA、AST、ALP水平显著低于对照组，观察组患者妊娠终止时间长于对照组，产后出血量显著少于对照组，新生儿体质量明显重于对照组，差异均有统计学意义（P＜0．05）。结论饮食疗法联合优思弗应用于妊娠期胆汁淤积症患者，可以有效缓解患者瘙痒症状，改善患者生化指标，延长妊娠终止时间，减少术后大出血及增加新生儿质量，值得临床推广应用。%Objective To investigate the effects of diet therapy combined with ursofalk on the outcomes of pa‐tients with intrahepatic cholestasis of pregnancy .Methods 80 cases of patients with intrahepatic cholestasis of preg‐nancy and bad eating habits admitted in the First Affiliated Hospital of Chengdu Medical College were selected as study objects and divided into control goup and observation group .The patients in control group were treated by ur‐sofalk alone ,and the patients in observation group were treated by diet therapy combined with ursofalk .After 1 -month treatment ,the pruritus scores ,biochemical indexes and pregnancy outcomes of two groups were assessed and compared .Results There was no significant difference of the pruritus scores between control group and observation group before treatment ,however ,the pruritus score of observation group was significantly lower than that of control group after treatment .After treatment ,the levels of TBA and AST of control group significantly reduced ,the levels of TBA ,AST and ALP of observation group reduced significantly and were lower than those of control group .Obser‐vation group had longer pregnancy termination time ,less postpartum hemorrhage ,and higher neonatal weight than control group ,with statistical differences .Conclusion Diet therapy combined with ursofalk appling in patients with cholestasis of pregnancy ,could effectively alleviate the symptoms of itching ,improve biochemical indexes ,prolong the pregnancy termination time ,reduce postoperative bleeding and increase neonatal weight ,which was worth of promo‐tion in clinic .