血清基质细胞趋化因子-1αC 反应蛋白水平与妊娠糖尿病胰岛素抵抗相关性研究

摘要

目的：探讨妊娠糖尿病患者血清中基质细胞趋化因子-1α(SDF-1α)、C 反应蛋白(CRP)的水平与胰岛素抵抗的相关性。方法选取孕妇60例,按照有无妊娠糖尿病分为对照组30例和妊娠糖尿病组30例。采用酶联免疫吸附试验(ELISA)检测孕妇血清 SDF-1α水平,免疫荧光法测定 CRP；同时测定空腹血浆胰岛素(FINS)、血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)等；计算胰岛素抵抗指数(HOME-IR)。结果妊娠糖尿病组血清中 SDF-1α、CRP 明显高于对照组(P <0.05)、SDF-1α与 CRP 呈正相关,SDF-1α、CRP 与 FBG、FINS、HbA1c、HOME-IR 呈正相关。结论SDF-1α、CRP 与妊娠糖尿病胰岛素抵抗密切相关,参与了其发病机制。%Objective To investigate the correlation between the stromal cell chemotactic factor (SDF-lα)and C-reactive protein (CRP)levels with insulin resistance in the patients with gestational diabetes.Methods 60 preg-nant women in our hospital from January to November 2014 were selected and divided into the healthy control group (30 cases)and the gestational diabetes group(30 cases)according to with or without gestational diabetes.The en-zyme-linked immunosorbent assay (ELISA)was adopted to detect the serum SDF-1αlevel,CRP was measured by im-munofluorescence,at the same time fasting plasma insulin (FINS),fasting blood glucose (FBG),triglyceride (TG);total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin (HbAlC)were detected;the insulin resistance index(HOMA-IR)was calculated.Results The serum SDF-1α and CRP levels in the gestational diabetes group were significantly higher than those in the healthy control group (P <0.05),SDF-αand CRP was positively correlated,SDF-1αand CRP were positively corre-lated with FBG,FINS,HbA1c and HOMA-IR.Conclusion SDF-1α and CRP are closely correlated with the insulin resistance in gestational diabetes and involved in its pathogenesis.