广西地区不同民族食管癌患者手术前后免疫功能研究

摘要

Objective To explore the influence of immune function about operation treatments for patients with esophageal carcinoma(EC) in Guangxi different nationalities .Methods Whole blood and serum of 123 cases were respectively collected in EC patients before and after radical resection of esophageal carcinoma;the content of IL‐2 ,IL‐6 ,IL‐10 and IL‐23 were detected;the differences of the immune index among different ethnic groups or in the same nation before and after radiation treatments were statistically analyzed .Results IL‐2 was significant different in the different nationalitily patients before radical resection of esophageal carcinoma;the level of IL‐2 was significant differences between Han patients after radical resection of EC ;the level of IL‐23 was significant differences between Zhuang and Han patients after radical resection of EC(P< 0 .05) .Conclusion The body′s immune function exist differences in different nationalities of esophageal patients .And radical resection of esophageal carcinoma for patients immune function had different impact among four nationalities .%目的：探讨广西地区不同民族食管癌患者手术前后免疫功能状态。方法利用酶联免疫吸附法检测123例食管癌患者手术前后外周血白细胞介素2（IL‐2）、白细胞介素6（IL‐6）、白细胞介素10（IL‐10）及白细胞介素23（IL‐23）水平。结果手术前IL‐2水平在汉族、壮族、苗族、瑶族食管癌患者之间比较，差异有统计学意义（P＜0．05），IL‐6、IL‐10、IL‐23水平在不同民族患者之间差异无统计学意义（ P＞0．05）；手术后IL‐2、IL‐6、IL‐10、IL‐23水平在汉族、壮族、苗族、瑶族食管癌患者中差异无统计学意义（ P＞0．05）；手术前后IL‐2、IL‐23水平比较，汉族患者术前均高于术后，壮族患者IL‐23水平术前高于术后（ P＜0．05）。结论广西地区汉族、壮族、苗族、瑶族食管癌患者免疫功能状态存在一定差异，手术对汉族及壮族食管癌患者的免疫功能影响较大，而对苗族及瑶族患者无影响。