目的：探讨冠心病患者外周血内皮细胞膜微粒（EMPs）、辅助性 T细胞（Th）细胞因子水平变化及临床意义。方法选择2011年7月至2013年7月孝感市中心医院收治的68例冠心病患者作为研究对象，按照世界卫生组织分类标准分为稳定型心绞痛（SA）21例，不稳定心绞痛（UA）22例，急性心肌梗死（AMI）25例；另选择同期在孝感市中心医院体检的健康人群30例作为健康对照组。比较4组受检者外周血EM Ps、γ干扰素（IFN‐γ）、白细胞介素‐2（IL‐2）、IL‐4、IL‐10水平。结果4组受检者中，SA组、UA组、AMI组外周血 EMPs、IFN‐γ、IL‐2水平均显著高于健康对照组，其中UA组和AMI组水平又高于SA组，差异均有统计学意义（P＜0．05）；AMI组外周血EMPs显著高于UA组，差异有统计学意义（P＜0．05）。相关性分析结果显示，EMPs与IFN‐γ、IL‐2呈正相关关系（P＜0．05），而与IL‐4、IL‐10无明显相关性（P＞0．05）。结论冠心病患者外周血EMPs水平能够反映患者内皮功能、斑块炎性反应程度及斑块稳定性；导致EM Ps升高的原因可能与T h1／T h2细胞因子分泌异常有关。%Objective To explore the changes and clinical significance of endothelial cell membrane particles (EMPs) ,helper T cell (Th) levels in patients with coronary heart disease .Methods Totally 68 cases of patients with coronary heart disease from July 2011 to July 2013 in the hospital were selected as the research object ,according to the WHO classification standards ,stable angina pectoris (SA) in 21 patients ,unstable angina pectoris (UA) in 22 cases ,acute myocardial infarction (AMI) in 25 cases;30 cases of health the same period in the hospital were selected as the control group .The levels of EMPs ,IFN‐γ,IL‐2 ,IL‐4 ,IL‐10 in the four groups were compared .Results The SA group ,UA group ,AMI group of peripheral blood EMPs ,IFN‐γ,IL‐2 levels were significantly higher than those in the control group ,UA group and AMI group was higher than that of SA group (P<0 .05);peripheral blood EMPs in AMI group was higher than that in UA group (P<0 .05) .The results of correlation analysis showed EMPs and IFN‐γ,IL‐2 was positively related (P<0 .05) ,and had no significant correlation between IL‐4 ,IL‐10 (P>0 .05) .Conclu‐sion The level of EMPs in peripheral blood of patients with coronary heart disease can reflect the degree of inflam‐mation ,endothelial function and plaque stability ;possible reasons leading to elevated EMPs and Th1/Th2 cytokine se‐cretion abnormalities .
展开▼
