Objective To explore thymic stromal lymphopoietin (TSLP) expression on the prognosis of patients with gastric cancer .Methods A total of 110 patients with gastric cancer were collected .Immunohistochemistry was used to test TSLP expres‐sion in non‐cancerous gastric tissue and gastric cancer tissue from patients with gastric cancer .Results TSLP expression in the ear‐ly stage of gastric cancer ,including T 1 stage and 1 - 2 clinical stage ,were significantly higher than the later stage of gastric cancer (T2 to T4 stage) (P< 0 .05) .And the expression of TSLP in lymph node metastasis (P= 0 .001) ,liver metastasis (P= 0 .024) ,pos‐itive peritoneal lavage cytology (P= 0 .016) ,lymphatic invasion (P= 0 .001) and vascular invasion (P= 0 .011) were significantly higher than that of non‐cancerous gastric tissue .The prognosis of patients with positive expression of TSLP was worse than that of patients without expression of TSLP .Multivariate analysis identified that serum TSLP level was an independent risk indicator for the prognosis of patients with gastric cancer (P= 0 .001 ,H R = 3 .537 ,95% CI :1 .632 - 7 .666) .Conclusion TSLP is closely related to the progression of in patients with gastric cancer ,which could be used as an indicator in evaluating the prognosis of patients with gastric cancer .%目的：探讨胸腺基质淋巴细胞生成素（TSLP）表达水平对胃癌患者预后的影响。方法选择2003－2012年经病理方法确诊的胃癌患者110例，采用免疫组织化学方法检测胃癌与临近非肿瘤组织中 TSLP 表达情况。结果结果提示与早期胃癌（T1期和临床1～2期）患者相比 TSLP 在晚期胃癌（T2、T3、T4期和临床3～4期）中表达率更高，差异有统计学意义（P ＜0．05）。在淋巴结转移（P＝0．001）、肝脏转移（P＝0．024）、腹腔灌洗细胞学检查阳性（P＝0．016）、淋巴管侵入（P＝0．001）和血管侵入（P＝0．011）患者中 TSLP 表达升高，差异有统计学意义（P＜0．05）。 TSLP 表达阴性患者的疾病预后显著优于表达阳性患者。多重变量分析结果表明，TSLP 表达增高是胃癌患者疾病预后不良独立标志物（P ＝0．001，H R ＝3．537，95％ CI ：1．632～7．666）。结论 TSLP 表达与胃癌进展密切相关，TSLP 表达可以作为评价胃癌患者疾病预后的重要指标。
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