幽门螺旋杆菌感染与Sox2蛋白在胃癌发病中的相关性研究

摘要

目的 探讨幽门螺旋杆菌(Hp)感染与Sox2蛋白在胃癌发病中的相关性.方法 选取2011年1月至2016年4月该院收治的胃癌患者90例作为研究对象(观察组),另取同期于该院体检的30例健康者作为对照组.比较两组间Hp感染率、Sox2表达阳性率以及观察组中两者与病理参数间的相关性.结果 观察组Hp感染率、Sox2表达阳性率分别为71.1％、58.9％,对照组分别为33.3％、93.3％,组间比较观察组Hp感染率高于对照组,而Sox2表达阳性率低于对照组,差异有统计学意义(P＜0.05).不同肿瘤直径、浸润程度、分化程度及TNM分期组间的Hp感染率不同(P＜0.05);Sox2蛋白表达阳性率则与浸润程度、分化程度及TNM分期存在显著相关性(P＜0.05).胃癌Hp感染与Sox2蛋白表达呈负相关(r=-0.798 1,P＜0.05).结论 Hp与Sox2均与胃癌的发生、发展存在显著相关性,且两者之间呈负相关,可视为重要标志物应用于胃癌的诊断及预后评价中.%Objective To study the correlation of Hp infection and Sox2 protein in the attack of gastric cancer.Methods 90 patients with gastric cancer treated from January 2011 to April 2016 in our hospital were selected as observation group.30 healthy check-ups were selected as control group.The Hp infection rate,positive rate of Sox2 protein as well as their correlation with pathological parameters were recorded.Results The Hp infection rate and positive rate of Sox2 protein for observation group were 71.1％ and 58.9％;the rate for control group were 33.3％ and 93.3％ (P＜0.05);the Hp infection rate based on the different diameters of tumor,infiltration degree,differentiation degree and TNM staging were significantly different (P＜0.05);the positive rate of Sox2 protein had an obvious correlation with infiltration degree,differentiation degree and TNM staging (P＜0.05);the Hp infection had a negative correlation with the expression of Sox2 protein (r=-0.798 1,P＜0.05).Conclusion Hp and Sox2 has an obvious correlation with the development of gastric cancer;Hp infection has a negative correlation with the expression of Sox2 protein.It is of great importance in the diagnosis and prognosis of gastric cancer.