经皮胫神经电刺激治疗女性膀胱过度活动症的临床疗效

摘要

Objective To investigate the clinical efficacy of percutaneous tibial nerve stimulation(PTNS) in treating the female patients with overactive bladder.Methods A total of 40 female patients with overactive bladder were enrolled in this study,patients received PTNS for 8 weeks(one time a day,30 minutes each time,5 times a week).Urinary BDNF levels,overactive bladder symptom scores(OABSS) and King′s Health Questionnaire scores(KHQ) were used to assess treatment effects.Safety was also evaluated.Results The scores of BDNF/Cr,OABSS and KHQ after the treatment were significantly lower than before(P<0.05).The total effective rate was 82.5%(33/40).No serious adverse events occurred in all patients.Conclusion PTNS is effective and safe for female patients with overactive bladder,so it is worthy of promotion.%目的 观察经皮胫神经电刺激(PTNS)治疗女性膀胱过度活动症(OAB)的临床疗效,并比较治疗前后患者尿液中脑源性神经营养因子(BDNF)的变化.方法 选择2015年2月到2016年8月在该院泌尿外科就诊的女性OAB患者40例,应用PTNS治疗8周(每天1次,每次30 min,每周治疗5次),比较治疗前后患者尿液中BDNF、膀胱过度活动症状评分(OABSS)、King健康问卷评分(KHQ)等指标的变化,并记录治疗中的不良反应.结果 治疗后40例患者,尿液中BDNF/Cr、OABSS、KHQ均显著降低,与治疗前比较差异均有统计学意义(P<0.05),总有效率82.5%(33/40),无明显不良反应发生.结论 PTNS治疗女性OAB临床疗效显著,且经济、安全,值得在临床中推广应用.