胰岛素泵强化治疗对初诊2型糖尿病患者氧化应激水平的研究

摘要

目的 探讨胰岛素泵强化治疗对初诊2型糖尿病患者氧化应激水平的影响.方法 选取该院诊治的初诊2型糖尿病患者70例,随机分为治疗组与对照组,各35例.治疗组患者采用胰岛素泵进行治疗,对照组患者使用多次皮下胰岛素注射治疗,治疗时间均为2周.检测2组患者空腹胰岛素(FPG)、餐后2小时胰岛素(2 hPG)、糖化血红蛋白(HbA1c)及超氧化物歧化酶(SOD)、还原型谷胱甘肽(rGSH)、血8-异前列腺素F2α的变化情况,并进行比较.结果 治疗后,2组患者FPG、2 hPG及HbA1c较治疗前均有一定程度下降,差异有统计学意义(P<0.05).治疗组SOD、rGSH及血8-异前列腺素F2α水平优于对照组,差异有统计学意义(P<0.05).结论 胰岛素治疗初诊2型糖尿病患者有较好疗效,且胰岛素泵短期强化治疗能在稳定降糖的同时改善氧化应激及减少炎性反应发生.%Objective To explore insulin pump intensive treatment on the influence of the first diagnosis in patients with type 2 diabetes oxidative stress level.Methods 70 patients with newly diagnosed type 2 diabetes mellitus were selected and randomly divided into treatment group(n=35)and control group(n=35).Treatment group patients was treated with insulin pump,the control group was used multiple subcutaneous insulin injections as control,treatment time was 2 weeks.Observed and compared the two groups of patients with fasting insulin,insulin,2 hours after meal glycosylated hemoglobin and superoxide dismutase,reduced glutathione and blood eight different changes of the prostaglandin F2α.Results After two weeks of insulin therapy,all patients on an empty stomach,2 hours after the meal,insulin and glycosylated hemoglobin had certain degree of decline,the difference was statistically significant (P<0.05);Superoxide dismutase,reduced glutathione and blood treatment group of eight different prostaglandins F2 alpha variation were better than those of control group,the difference was statistically significant (P<0.05).Conclusion Insulin has good curative effect in patients with type 2 diabetes,and insulin pump short-term intensive therapy can improve oxidative stress at the same time in the stability of hypoglycemic and reduce inflammation.