Objective To discuss the expression and variation tendencies of cerebrospinal fluid cystatin C (Cys C) and mpt in nerve system diseases.Methods A total of 204 patients undergoing multiple cerebrospinal fluid biochemical marker detections,including the expression levels of cerebrospinal fluid Cys C and mpt in 14 kinds of diseases were analyzed before and after treatment,the differences in concentrations as well as variation tendency between Cys C and mpt were compared before and after treatment,and their expression modes in different disease groups were analyzed independently and jointly.Results Cerebrospinal fluid mpt generally decreased,while the proportion of patients in the lower interval of Cys C generally tended to gradually increase,and which decreased in a higher level interval.The variation tendency of Cys C concentration and those of different regions were independent from that of mpt,while both the initial level intervals of Cys C and mpt were correlated with the distribution intervals after treatment.The variation tendencies of Cys C and mpt concentrations before and after treatment showed no correlation with disease groups,and the migration tendency of Cys C after divisional treatment was not correlated with disease groups,while the migration tendency of mpt after divisional treatment was associated with disease groups.Through,a joint observation of Cys C and mpt could be seen that the testing results of Cys C and mpt in the joint divisional group were correlated with disease groups before and after treatment,and the joint variation tendency of Cys C and mpt distribution intervals were correlated with disease groups.Conclusion The expression levels and variation tendencies of cerebrospinal fluid Cys C before and after treatment are different from mpt,and the variation tendency still have differential expressions before and after treatment.The single use of spinal fluid Cys C is still limited,but its combination with mpt may play a positive role in the diagnosis and treatment monitoring of nerve system diseases.%目的 探讨脑脊液胱氨酸蛋白酶抑制剂C(Cys C)及脑脊液总蛋白(mpt)在多种神经系统疾病中的动态表达及变化趋势分析.方法 分析进行过多次脑脊液生化标志物检测的14种疾病共计204例患者的脑脊液Cys C与mpt首次检测及末次检测的表达水平,对比Cys C及mpt的首次检测后水平的差异及其变化趋势,并对在不同疾病组的表达模式进行单独分析及联合分析.结果 脑脊液mpt末次检测整体呈现下降的趋势,而Cys C末次检测在低水平范围患者所占比例上升、而高水平范围患者所占比例下降;Cys C水平的变化与mpt的水平变化相互独立,但Cys C及mpt的首次检测水平的分布均分别与末次检测的分布相关(P=5.0×10-4);首次治疗后Cys C变化趋势与疾病分组不相关而mpt治疗水平变化与疾病分组相关;患者Cys C末次检测亦与疾病类型不相关,而mpt末次检测与疾病类型相关;联合检测Cys C及mpt可见,首次检测后Cys C和mpt联合分组均与疾病类型相关(P=5.0×10-4,0.02).结论 脑脊液Cys C的表达水平及变化趋势均不同于mpt,脑脊液Cys C单独应用价值仍然有限,联合脑脊液中mpt可以在多种神经系统疾病的鉴别诊断及治疗过程监测产生积极的作用.
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