目的：研究胃癌患者组织中IL‐1β、IL‐6的表达水平与幽门螺杆菌（Hp）感染的相关性分析。方法选择2013年3月至2015年1月接诊的60例胃癌患者为观察组，60例参与研究的健康志愿者为对照组。采用免疫组织化学法和快速尿素酶法检测法分别检测两组胃组织中IL‐1β、IL‐6表达情况以及 H p感染情况。结果观察组IL‐1β、IL‐6表达水平明显高于对照组，差异有统计学意义（P＜0．05）。观察组Hp感染情况明显高于对照组，差异有统计学意义（P＜0．05）。观察组和对照组中 Hp感染患者的IL‐1β、IL‐6表达与未受感染患者比较，差异有统计学意义（ P＜0．05）。结论 IL‐1β、IL‐6水平升高可能导致胃癌的形成， Hp感染可能与胃癌形成具有相关性。%Objective To investigate the correlation between the expression of IL‐1βand IL‐6 in gastric cancer with Helicobacter pylori(Hp) infection in the patients with gastric cancer .Methods Sixty cases of gastric cancer in our hospital from March 2013 to January 2015 were selected and 60 healthy volunteers participating in this research were taken as the control group .The IL‐1βand IL‐6 levels in gastric tissue were detected by using the immunohistochemistry and the Hp infection was detected by adopting the rapid urease method .Results The levels of the IL‐1βand IL‐6 in the observation group were significantly higher than those in the control group ,the difference had statistical significance (P<0 .05);the Hp infection in the observation group was significantly high‐er than that in the control group ,the difference was statistically significant (P<0 .05);the IL‐1βand IL‐6 expression levels in the observation group and control group had statistical difference between the Hp infection patients and non‐Hp infection patients(P<0 .05) .Conclusion Increase of IL‐1βand IL‐6 levels may lead to the formation of gastric cancer and Hp infection may be associated with gastric carcinogenesis .
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