右美托咪定与利多卡因联合输注对乳腺肿瘤切除术后疼痛和恶心呕吐的影响

摘要

Objective To investigate the effects of combination of dexmedetomidine and lidocaine on pain, nausea and vomiting after resection of breast tumor.Methods A total of 80 patients were divided into two groups according to the method of random number,the control group and the observation group.Each group had 40 patients.The control group was treated with lidocaine by continuous intravenous pumping,and the ob-servation group adopted dexmedetomidine combined with lidocaine.The anesthetic effect of the relevant indi-cators were compared.Results The amount of propofol,recovery time of orientation and recovery room resi-dence time of control group were significantly higher than that of the observation group(P<0.05).And NRS scores of 6 h after the operation and rates of nausea and vomiting of the control group were significantly lower than that of the observation group(P<0.05).The difference of operation time and extubation time between the two groups had no statistical significance(P> 0.05).Conclusion The adopted anesthetic method of dexmedetomidine combined with lidocaine in breast tumor resection patients has better effect than the use of lidocaine alone,w hich could improve postoperative pain and reduce postoperative nausea and vomiting.%目的 探讨右美托咪定与利多卡因联合使用对乳腺肿瘤切除患者术后疼痛和恶心呕吐的影响.方法 选择2015年1月至2016年9月该院乳腺外科进行单纯乳腺肿瘤切除术的患者80例,按照随机数字表法分为对照组和观察组,每组40例.对照组患者在手术过程中持续静脉泵注利多卡因,观察组患者则先进行右美托咪定的静脉泵注,然后在手术过程中持续泵注利多卡因,对两组麻醉效果的指标进行比较.结果 对照组和观察组患者丙泊酚使用量、定向力的恢复时间、麻醉后恢复室停留时间、手术后6 h的疼痛数字评分(N RS评分)、恶心呕吐的发生情况比较差异有统计学意义(P<0.05).其中,观察组的丙泊酚使用量、定向力的恢复时间和麻醉后恢复室停留时间均高于对照组(P<0.05),而手术后6 h的NRS评分和恶心呕吐发生情况低于对照组(P<0.05).两组的手术时间、拔管时间比较差异无统计学意义(P>0.05).结论 对乳腺肿瘤切除手术患者采用右美托咪定与利多卡因联合输注进行麻醉,比单纯使用利多卡因效果更好,可明显改善手术后疼痛,减少术后恶心呕吐现象的发生.