Objective By sampling for cosmetics sold in some cities in Hebei,the situation of safety toxicological of the cosmetics was investigated.Method Using the animal experiments method,the 33 cosmetics were tested on toxicology.The cosmetic samples collected from markets,they were the beauty cream,sunscreen,facial cleanser and body wash and so on.Result Nineteen cosmetics (8 of body wash,8 of facial cleanser and 3 of beauty cream) in rabbits acute skin irritation test that resulted for non-irritating 10 cases (52.6％),9 cases of mild irritant (47.4％);16 samples (8 of body wash and 8 of facial cleanser) in rabbits eye irritation test resulted for 0 cases of non-irritating reaction,micro stimulation 3 cases (18.8％),13 cases of mild stimulation (81.2％);The results of 17 samples (3 of beauty cream,9 of Sunscreens and 5 of Freckle cream) in the guinea pig skin allergy tests displayed that the weakly and mild allergenic reaction were total of 3 cases (17.6％),and no allergic reactions in 14 cases (82.4 ％).Conclusion Survey results show that all kinds of cosmetics have different proportions of light (or micro) of the toxicological response.Although it can be determined that the products under investigation are acceptable for the human,but suggested that the regulatory authorities should attach importance to and strengthen risk monitoring,in order to protect the safety of consumers.%目的 通过抽样测试,对河北省内部分城市(2011-2012年)市售化妆品安全性毒理学状况进行调查.方法 采用动物试验方法,对市场采集的祛斑类、防晒类、洗面类及沐浴类等33个化妆品进行安全毒理学试验观察.结果 19个化妆品(沐浴类8个,洗面类8个,祛斑洁面类3个)对家兔的急性皮肤刺激性试验结果:无刺激性10例(52.6％),轻刺激性9例(47.4％);16个样品(沐浴类8个,洗面类8个)对家兔急性眼刺激试验结果:无刺激性0例、微刺激性3例(18.8％)、轻刺激性13例(81.2％);17个样品(祛斑洁面类3个,防晒类9个,祛斑类5个)对豚鼠的皮肤变态反应试验结果:14例无致敏反应(82.4％),出现弱致敏性和轻致敏性反应的共有3例(17.6％).结论 调查显示,各类化妆品均有不同比例的轻(或微)度毒理学反应,虽然可以判定所调查产品均在人类可接受范围之内,但提示监管部门应重视和加强风险监控,以保障消费者安全.
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