本文综述了近20年来国内外有关先天性、创伤性、人工诱导性和细胞水平白内障动物模型的建立方法、特点及相关机制研究,总结了各类型白内障动物模型构建的评价指标,提出了建立晶状体永生化细胞系,研究白内障发病过程晶状体细胞中基因表达水平的变化,以及建立与人类较相似的白内障树鼩模型的研究设想.%This paper summarized the method for establishing animal models of congenital, traumatic, artificially induced and cellular-level cataract that have been studied at domestic and abroad in nearly resent 20 years. The characteristics, evaluation criteria and related mechanisms of each model were also described. The paper also proposesed a method for studying the expression of gene in lens cells that in different state of cataract by established immortalized lens cell lines, and an assumption that setting up tree shrew model for cataract that are similar to human cataract.
展开▼
