抗原处理相关转运体基因多态性与疾病相关性的研究进展

摘要

Transporter associate with antigen processing (TAP) is a heterodimer which plays a crucial role in antigen presenting process by transporting endogenous antigen peptide from the cytoplasm to the endoplasmic reticulum where can be bound by the major histocompatibility complex (MHC) class Ⅰ molecules and further be recognized by CD8+T lymphocyte.Polymorphisms of TAP gene and the expression level of TAP protein are associated with susceptibility to certain specific diseases including tumor,autoimmune disease,viral disease and infectious diseases.Here,some similar comparative medicine researches of TAPs in laboratory animals to diseases associations are reviewed.%抗原处理相关转运体(TAP)是一种异二聚体跨膜转运蛋白,具有高度多态性,主要功能是将胞质中加工产生的抗原肽转运到内质网腔,与主要组织相容复合体(MHC)Ⅰ类分子组装形成抗原肽一MHCI复合物后转运至细胞表面,被CD8+T淋巴细胞识别,诱导机体产生细胞免疫应答.某些特定的人类疾病同TAP的多态性相关,包括多种肿瘤疾病、自身免疫疾病和传染性疾病等.本文就实验动物的TAP基因在与疾病相关性方面的比较医学研究进展做一综述.