目的：通过检测咬合关系丧失患者在咬合重建修复后不同时间点大脑中动脉血流速度和脑组织血氧饱和度的变化，探讨咬合重建修复治疗对脑组织氧供应的影响。方法：选择2011年2月—2013年10月在湖州师范学院附属第一医院口腔科接受治疗的咬合关系丧失患者33例，行咬合重建修复治疗后，应用经颅多普勒彩色超声诊断仪和近红外线光谱仪分别检测患者进行义齿修复前和修复后3、6、12个月在平静和咀嚼运动状态下的大脑中动脉收缩期峰流速（vS）、舒张期末峰流速（ vd ）、平均峰流速（ vm ）值和脑组织血氧饱和度（ rScO2）。结果：平静状态下，咬合重建修复后3个月vm 即加快，6个月后vS 和vd 也加快（ P ＜0．05），而rScO2则在治疗后12个月才增加。在咀嚼运动状态下，咬合重建修复后3个月， vS、vm 和rScO2均增加；治疗后6个月，vd 也增加（ P＜0．05）。结论：咬合重建修复治疗可以提高咬合关系丧失患者大脑中动脉血流速度和脑组织血氧饱和度，对改善脑氧供应和脑功能有促进作用。%Objective: To investigate the effect of occlusal reconstruction on blood flow velocity and cerebral oxygen saturation in patients with malocclusion .Methods:Thirty-three patients with malocclusion treated with occlusal reconstruction in Department of Stomatology , Medical School of Huzhou Normal College from Feb 2011 to Oct 2013 were enrolled in the study .The systolic peak flow velocity ( vs ) , end-diastolic peak flow (vd) , mean peak flow velocity (vm) of middle cerebral artery and the oxygen saturation ( rScO2 ) in the brain were detected at rest or chewing status by using transcranial Doppler color ultrasonography and near-infrared spectroscopy , respectively . Results:In rest state, vm was significantly increased on 3 months after treatment, while vs and vd were significantly increased on 6 months after treatment and rScO2 were increased on 12 months after treatment (P<0.05).In chewing state, vs, vm, and rScO2 were increased on 3 months after treatment , and vd was increased on 6 months after treatment (P<0.05).Conclusion: Occlusal reconstruction can increase blood flow velocity of middle cerebral artery and cerebral oxygen saturation and improve oxygen supply of the brain in patients with malocclusion .
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