固精汤结合帕罗西汀治疗早泄60例疗效分析

摘要

[Objective] A randomized control ed trial of traditional Chinese medicine recipe Gujing Tang treatment of premature ejaculation was studied. [Methods] The subjects: 60 patients with premature ejaculation form department of andrologic outpatient, the patients were randomly divided into two groups, Integrated TCM-WM Groups and paroxetine Groups. 30 cases in each group. The Integrated TCM-WM Groups were given Gujing Tang , with paroxetine 10mg, oral, Qd at the same time; The paroxetine groups were given paroxetine 10mg, oral, Qd. Both groups were treated for 3 months. Ejaculation status was evaluated at the timepoint:before treatment, 3 months after treatment,and fol ow-up evaluation of six months after treatment. Evalu-ate parameter including Intravaginal ejaculation latency(IELT) and score of sexual function and Chinese patients with premature ejaculation evaluation -5 (CIPE-5). [Results] After 3 months, both groups were significantly improved, and Integrated TCM-WM Groups improved more significantly. After 6 months of fol ow-up, IELT, motion times and CIPE-5 score of Integrated TCM-WM Groups decreased slightly, but stil had significant difference com-pared to before treatment, and this parameter of Paroxetine groups was returned to the level of baseline, and had no significant difference compared with baseline. [Conclusion] Traditional Chinese medicine Recipe Gujing Tang combined with paroxetine, could not only have rapid onset, enhance patient confidence, improve the psychological state, but also improve the long-term efficacy and avoid recurrent disease after treatment, therefore can achieve ef-fective treatment of premature ejaculation.%[目的]研究固精汤结合帕罗西汀对早泄（premature ejaculation, PE）的治疗效果。[方法]将2007年1月至2010年6月浙江省中医药大学附属第一医院泌尿外科就诊的早泄患者60例随机分为固精汤组和帕罗西汀组，每组30例。帕罗西汀组予以帕罗西汀10mg,口服，1次/晚；固精汤组在帕罗西汀组基础上加予固精汤，两组均治疗3个月。在入组前、治疗3个月后、停药后半年随访时使用计时和阴道内抽插次数两种方法评估的阴道内射精潜伏期（intravaginal ejaculation latency time, IELT）、中国早泄患者性功能评价表-5（CIPE-5）评价患者射精状态。[结果]治疗3个月后，两组患者IELT、抽插次数评分和CIPE-5评分均得以明显改善，而固精汤组改善更为明显。6个月后随访时固精汤组IELT、抽插次数评分及CIPE-5略有下降，但与治疗前相比，差异有统计学意义(P＜0.05)，而帕罗西汀组各项指标则回至接近治疗前水平，与治疗前相比无明显差异(P＞0.05)。[结论]固精汤联合帕罗西汀，既能快速起效、增强患者自信心、改善性心理状态，又能提高远期疗效、避免停药后病情反复，能有效治疗PE。